{"id":36922,"date":"2024-09-29T13:54:52","date_gmt":"2024-09-29T17:54:52","guid":{"rendered":"https:\/\/ckms.ca\/?p=36922"},"modified":"2024-09-29T13:54:52","modified_gmt":"2024-09-29T17:54:52","slug":"preclinical-studies-suggest-a-drug-free-nasal-spray-could-ward-off-respiratory-infections","status":"publish","type":"post","link":"https:\/\/blog.ckms.ca\/?p=36922","title":{"rendered":"Preclinical studies suggest a drug-free nasal spray could ward off respiratory infections"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/earimediaprodweb.azurewebsites.net\/Api\/v1\/Multimedia\/0244d35b-e343-4af6-8ec4-baa5ecce07b2\/Rendition\/low-res\/Content\/Public\" alt=\"\" width=\"316\" height=\"447\" \/><span style=\"font-size: inherit;\">A new study details how a nasal spray formulated by investigators from Brigham and Women\u2019s Hospital, a founding member of the Mass General Brigham healthcare system, may work to protect against viral and bacterial respiratory infections<\/span><\/p>\n<p>Source: <em><a href=\"https:\/\/www.eurekalert.org\/news-releases\/1058971\">Preclinical studies suggest a drug-free nasal spray could ward off respiratory infections<\/a><\/em><\/p>\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p>fta:<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>The new study details the research team\u2019s efforts to create a nasal spray to defend against airborne respiratory illness. \u201cThe spray, called Pathogen Capture and Neutralizing Spray (PCANS) in the paper, was developed using ingredients from the FDA\u2019s Inactive Ingredient Database (IID), which have been previously used in approved nasal sprays, or from the Generally Recognized as Safe (GRAS) list of the FDA,\u201d said co-senior author Nitin Joshi, PhD, an Assistant Professor of\u00a0<a href=\"https:\/\/www.brighamandwomens.org\/anesthesiology-perioperative-and-pain-medicine\">Anesthesiology<\/a>\u00a0at Brigham and Women\u2019s Hospital. \u201cWe developed a drug-free formulation using these compounds to block germs in three ways \u2014 PCANS forms a gel-like matrix that traps respiratory droplets, immobilizes the germs, and effectively neutralizes them, preventing infection.\u201d<br>&#8230;<br>Experiments in mice showed that a single dose of the PCANS nasal spray could effectively block infection from an influenza virus (PR8) at 25 times the lethal dose. Virus levels in the lungs were reduced by >99.99%, and the inflammatory cells and cytokines in the lungs of PCANS-treated animals were normal.<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>A new study details how a nasal spray formulated by investigators from&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[282],"tags":[169,266],"class_list":["post-36922","post","type-post","status-publish","format-standard","hentry","category-article","tag-covid-19","tag-maybe-good","wpcat-282-id"],"_links":{"self":[{"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=\/wp\/v2\/posts\/36922","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36922"}],"version-history":[{"count":2,"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=\/wp\/v2\/posts\/36922\/revisions"}],"predecessor-version":[{"id":36924,"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=\/wp\/v2\/posts\/36922\/revisions\/36924"}],"wp:attachment":[{"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36922"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36922"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.ckms.ca\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36922"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}